In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol

Christopher J Lindsell; Anna McGlothlin; Samuel Nwosu; Todd W Rice; Alex Hall; Gordon R Bernard; Laurence W Busse; E Wesley Ely; Alpha A Fowler; David F Gaieski; Jeremiah S Hinson; Michael H Hooper; James C Jackson; Gabor D Kelen; Mark Levine; Greg S Martin; Richard E Rothman; Jonathan E Sevransky; Kert Viele; David W Wright; David N Hager

doi:10.1186/s13063-020-04290-6

In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol

Trials. 2020 Apr 22;21(1):351. doi: 10.1186/s13063-020-04290-6.

Authors

Christopher J Lindsell¹, Anna McGlothlin², Samuel Nwosu³, Todd W Rice⁴, Alex Hall^{5

6}, Gordon R Bernard⁴, Laurence W Busse⁷, E Wesley Ely^{8

9

10}, Alpha A Fowler¹¹, David F Gaieski¹², Jeremiah S Hinson¹³, Michael H Hooper¹⁴, James C Jackson^{8

9

10

15}, Gabor D Kelen¹³, Mark Levine¹⁶, Greg S Martin^{6

17}, Richard E Rothman¹³, Jonathan E Sevransky¹⁷, Kert Viele², David W Wright^{5

6}, David N Hager¹⁸

Affiliations

¹ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. chris.lindsell@vumc.org.
² Berry Consultants, LLC, Austin, TX, USA.
³ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴ Division of Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
⁵ Department of Emergency Medicine, Emory University, Atlanta, GA, USA.
⁶ Grady Memorial Hospital, Atlanta, GA, USA.
⁷ Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
⁸ Division of Pulmonary & Critical Care, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
⁹ Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, USA.
¹⁰ Tennessee Valley Veteran's Affairs Geriatric Research Education Clinical Center (GRECC), Nashville, TN, USA.
¹¹ Division of Pulmonary Disease & Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
¹² Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
¹³ Department of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA.
¹⁴ Division of Pulmonary & Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School and Sentara Healthcare, Norfolk, VA, USA.
¹⁵ Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.
¹⁶ Molecular & Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA.
¹⁷ Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Emory Critical Care Center, Atlanta, GA, USA.
¹⁸ Division of Pulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1800 Orleans Street, Suite 9121, Baltimore, MD, 21287, USA.

Abstract

ClinicalTrials.gov: NCT03509350. Registered on 26 April 2018.

Publication types

Letter

MeSH terms

Anti-Inflammatory Agents / therapeutic use*
Ascorbic Acid / therapeutic use*
Drug Therapy, Combination
Humans
Hydrocortisone / therapeutic use*
Sepsis / drug therapy*
Thiamine / therapeutic use*
Time-to-Treatment
Treatment Outcome
Vitamin B Complex / therapeutic use*

Substances

Anti-Inflammatory Agents
Vitamin B Complex
Ascorbic Acid
Hydrocortisone
Thiamine

Associated data

ClinicalTrials.gov/NCT03509350

Grants and funding

UL1 TR002649/TR/NCATS NIH HHS/United States