North American Prodrome Longitudinal Study (NAPLS 3): Methods and baseline description

Schizophr Res. 2022 May;243:262-267. doi: 10.1016/j.schres.2020.04.010. Epub 2020 Apr 18.


The North American Prodrome Longitudinal Study (NAPLS) is a consortium of nine programs focusing on youth at clinical high risk (CHR) for psychosis. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University, Harvard University, University of Calgary, University of California at Los Angeles, at San Diego, and at San Francisco, University of North Carolina Chapel Hill, Yale University, and Zucker Hillside Hospital. There have been two previous endeavors completed by this consortium, known as NAPLS-1 and NAPLS-2. This paper first offers an overview of the methodology of the third phase of the NAPLS consortium, the second five-year prospective study NAPLS-3, which aims to determine mechanisms of the development of psychosis. In addition, we report on the ascertainment and demographics of the 710 CHR participants in NAPLS-3.

Keywords: Clinical high risk; Methodology; Psychosis; Schizophrenia.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Humans
  • Longitudinal Studies
  • North America / epidemiology
  • Prodromal Symptoms*
  • Prospective Studies
  • Psychotic Disorders* / epidemiology