The North American Prodrome Longitudinal Study (NAPLS) is a consortium of nine programs focusing on youth at clinical high risk (CHR) for psychosis. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University, Harvard University, University of Calgary, University of California at Los Angeles, at San Diego, and at San Francisco, University of North Carolina Chapel Hill, Yale University, and Zucker Hillside Hospital. There have been two previous endeavors completed by this consortium, known as NAPLS-1 and NAPLS-2. This paper first offers an overview of the methodology of the third phase of the NAPLS consortium, the second five-year prospective study NAPLS-3, which aims to determine mechanisms of the development of psychosis. In addition, we report on the ascertainment and demographics of the 710 CHR participants in NAPLS-3.
Keywords: Clinical high risk; Methodology; Psychosis; Schizophrenia.
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Conflict of interest statement
Declaration of competing interest Authors declare they have no conflict of interest with respect to this study.
North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment.Schizophr Res. 2012 Dec;142(1-3):77-82. doi: 10.1016/j.schres.2012.09.012. Epub 2012 Oct 6. Schizophr Res. 2012. PMID: 23043872 Free PMC article.
Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study.JAMA Psychiatry. 2016 Dec 1;73(12):1239-1248. doi: 10.1001/jamapsychiatry.2016.2479. JAMA Psychiatry. 2016. PMID: 27806157 Free PMC article. Clinical Trial.
Duration of the psychosis prodrome.Schizophr Res. 2020 Feb;216:443-449. doi: 10.1016/j.schres.2019.10.051. Epub 2019 Dec 2. Schizophr Res. 2020. PMID: 31806523
North American Prodrome Longitudinal Study (NAPLS 2): The Prodromal Symptoms.J Nerv Ment Dis. 2015 May;203(5):328-35. doi: 10.1097/NMD.0000000000000290. J Nerv Ment Dis. 2015. PMID: 25919383 Free PMC article.
Stress and neurodevelopmental processes in the emergence of psychosis.Neuroscience. 2013 Sep 26;249:172-91. doi: 10.1016/j.neuroscience.2012.12.017. Epub 2013 Jan 5. Neuroscience. 2013. PMID: 23298853 Free PMC article. Review.