Transbronchial lung biopsy and bronchoalveolar lavage in diagnosis of diffuse infiltrative lung diseases

Respiration. 1988;54 Suppl 1:66-72. doi: 10.1159/000195479.


We investigated 801 patients with lung infiltrates who underwent transbronchial lung biopsy (TBB) and performed cytologic studies of lavage fluid of 491 patients who also underwent bronchoalveolar lavage (BAL). A specific histopathological diagnosis was made in 232 cases (29%). Histopathological changes consistent with the clinical pattern were present in 296 cases (37%). The diagnostic yield of TBB was 66%. Routine evaluation of BAL fluid allowed us to make a specific diagnosis in 49 cases. The role of the pulmonary pathologist in the interpretation of TBB and BAL specimens is discussed.

MeSH terms

  • Biopsy
  • Bronchoalveolar Lavage Fluid / cytology*
  • Humans
  • Lung / pathology*
  • Lung Diseases / pathology*
  • Lung Neoplasms / pathology