Direct in vivo comparison of [ 18 F]PSMA-1007 with [ 68 Ga]Ga-PSMA-11 and [ 18 F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Appl Radiat Isot. 2020 Jul;161:109164. doi: 10.1016/j.apradiso.2020.109164. Epub 2020 Apr 2.

Abstract

The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

Keywords: AlF-PSMA-11; Ga-PSMA-11; PSMA-1007; Preclinical; Prostate cancer.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Blood Proteins / metabolism
  • Cell Line, Tumor
  • Fluorine Radioisotopes / pharmacokinetics*
  • Gallium Radioisotopes / pharmacokinetics*
  • Heterografts
  • Humans
  • Male
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Niacinamide / analogs & derivatives*
  • Niacinamide / genetics
  • Niacinamide / pharmacokinetics
  • Oligopeptides / genetics
  • Oligopeptides / pharmacokinetics*
  • Positron Emission Tomography Computed Tomography / methods
  • Prostatic Neoplasms / diagnostic imaging
  • Prostatic Neoplasms / metabolism*
  • Tissue Distribution

Substances

  • Blood Proteins
  • Fluorine Radioisotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • PSMA-1007
  • Niacinamide