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. 2020 Apr;80(4):380-390.
doi: 10.1055/a-1134-5951. Epub 2020 Mar 26.

SARS-CoV-2 Infection in Pregnancy - A Review of the Current Literature and Possible Impact on Maternal and Neonatal Outcome

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SARS-CoV-2 Infection in Pregnancy - A Review of the Current Literature and Possible Impact on Maternal and Neonatal Outcome

Florian M Stumpfe et al. Geburtshilfe Frauenheilkd. .
Free PMC article

Abstract

In December 2019, cases of pneumonia of unknown cause first started to appear in Wuhan in China; subsequently, a new coronavirus was soon identified as the cause of the illness, now known as Coronavirus Disease 2019 (COVID-19). Since then, infections have been confirmed worldwide in numerous countries, with the number of cases steadily rising. The aim of the present review is to provide an overview of the new severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) and, in particular, to deduce from it potential risks and complications for pregnant patients. For this purpose, the available literature on cases of infection in pregnancy during the SARS epidemic of 2002/2003, the MERS (Middle East respiratory syndrome) epidemic ongoing since 2012, as well as recent publications on cases infected with SARS-CoV-2 in pregnancy are reviewed and reported. Based on the literature available at the moment, it can be assumed that the clinical course of COVID-19 disease may be complicated by pregnancy which could be associated with a higher mortality rate. It may also be assumed at the moment that transmission from mother to child in utero is unlikely. Breastfeeding is possible once infection has been excluded or the disease declared cured.

Keywords: 2019-nCoV; COVID-19; SARS-CoV-2; coronavirus; pregnancy.

Conflict of interest statement

Conflict of Interest/Interessenkonflikt The authors declare that they have no conflict of interest./Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.

Figures

Fig. 1
Fig. 1
Important milestones of the infections with SARS-CoV-2 since December 2019.
Abb. 1
Abb. 1
Wichtige Meilensteine der Infektionen mit SARS-CoV-2 seit Dezember 2019.

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