Background and aims: Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive. The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile.
Methods: A systematic literature search of online databases PubMed, Scopus, ISI Web of science, Cochrane's library and Google Scholar was conducted up to January 2019. Randomized controlled trials (RCTs) investigating the effects of synbiotics on lipid profile in adults were included. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model.
Results: A total of 23 RCTs with 1338 participants were included. Synbiotic consumption resulted in a significant decrease in plasma concentrations of total cholesterol (WMD = - 10.17 mg/dL; 95% CI - 15.74 to - 4.60; p < 0.001), triglyceride (WMD = - 14.30 mg/dL; 95% CI - 25.32 to - 3.28; p = 0.01), low-density lipoprotein cholesterol (WMD = - 8.32 mg/dL; 95% CI - 13.21 to - 3.43; p < 0.001), and an increase in plasma high-density lipoprotein cholesterol (WMD = 1.3 mg/dL; 95% CI 0.03 to 2.56; p = 0.04) levels compared to control (placebo supplements/control foods/conventional products). The effects are more pronounced when synbiotics supplements are consumed for > 8 weeks.
Conclusion: Synbiotic supplements may be beneficial to improve lipid profile, especially when they are consumed for > 8 weeks.
Keywords: Cholesterol; Lipid profile; Meta-analysis; Synbiotics; Triglyceride.
Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta-analysis of clinical trials.Crit Rev Food Sci Nutr. 2020;60(4):584-596. doi: 10.1080/10408398.2018.1545218. Epub 2018 Dec 30. Crit Rev Food Sci Nutr. 2020. PMID: 30595036
Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials.Phytother Res. 2019 Mar;33(3):534-545. doi: 10.1002/ptr.6264. Epub 2019 Jan 10. Phytother Res. 2019. PMID: 30632207
Effects of pro-/synbiotic supplementation on anthropometric and metabolic indices in overweight or obese children and adolescents: A systematic review and meta-analysis.Complement Ther Med. 2019 Jun;44:269-276. doi: 10.1016/j.ctim.2019.05.008. Epub 2019 May 8. Complement Ther Med. 2019. PMID: 31126565
Effects of cardamom supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled clinical trials.Phytother Res. 2020 Mar;34(3):475-485. doi: 10.1002/ptr.6543. Epub 2019 Nov 21. Phytother Res. 2020. PMID: 31755188 Review.
A PRISMA-compliant systematic review and meta-analysis of randomized controlled trials investigating the effects of statin therapy on plasma lipid concentrations in HIV-infected patients.Pharmacol Res. 2016 Sep;111:343-356. doi: 10.1016/j.phrs.2016.06.005. Epub 2016 Jun 25. Pharmacol Res. 2016. PMID: 27350264 Review.