B Cell Lymphoma

Adv Exp Med Biol. 2020:1254:161-181. doi: 10.1007/978-981-15-3532-1_12.


B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B cell survival or proliferation and consequently B lymphomagenesis. In fact, B cell lymphoma accounts for 95% of the lymphomas. In this chapter, we summarize the morphology, immunophenotypes, clinical features, genetic defects that cause the malignancies, treatments, and prognosis of the most prevalent types of B cell lymphomas, including typical precursor B cell malignance (B-ALL/LBL) and mature B cell lymphoma (Hodgkin lymphoma and B cell non-Hodgkin lymphoma).

Keywords: B cell non-Hodgkin lymphoma; B lymphoblastic leukemia/lymphoma; Chromosomal translocation; Hodgkin lymphoma; Molecular target therapy.

Publication types

  • Review

MeSH terms

  • B-Lymphocytes / metabolism
  • B-Lymphocytes / pathology
  • Humans
  • Immunoglobulin Class Switching
  • Lymphoma, B-Cell* / genetics
  • Lymphoma, B-Cell* / pathology
  • Somatic Hypermutation, Immunoglobulin
  • Translocation, Genetic