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. 2020 Apr 22;10.1111/ajt.15933.
doi: 10.1111/ajt.15933. Online ahead of print.

Solid Organ Transplantation Programs Facing Lack of Empiric Evidence in the COVID-19 Pandemic: A By-proxy Society Recommendation Consensus Approach

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Free PMC article

Solid Organ Transplantation Programs Facing Lack of Empiric Evidence in the COVID-19 Pandemic: A By-proxy Society Recommendation Consensus Approach

Paul V Ritschl et al. Am J Transplant. .
Free PMC article

Abstract

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has a drastic impact on national health care systems. Given the overwhelming demand on facility capacity, the impact on all health care sectors has to be addressed. Solid organ transplantation represents a field with a high demand on staff, intensive care units, and follow-up facilities. The great therapeutic value of organ transplantation has to be weighed against mandatory constraints of health care capacities. In addition, the management of immunosuppressed recipients has to be reassessed during the ongoing coronavirus disease 2019 (COVID-19) pandemic. In addressing these crucial questions, transplant physicians are facing a total lack of scientific evidence. Therefore, the aim of this study was to offer an approach of consensus-based guidance, derived from individual information of 22 transplant societies. Key recommendations were extracted and the degree of consensus among different organizations was calculated. A high degree of consensus was found for temporarily suspending nonurgent transplant procedures and living donation programs. Systematic polymerase chain reaction-based testing of donors and recipients was broadly recommended. Additionally, more specific aspects (eg, screening of surgical explant teams and restricted use of marginal donor organs) were included in our analysis. This study offers a novel approach to informed guidance for health care management when a priori no scientific evidence is available.

Keywords: clinical research/practice; guidelines; health services and outcomes research; infection and infectious agents-viral; infectious disease; organ acceptance; organ allocation; organ procurement; organ procurement and allocation; organ transplantation in general.

Conflict of interest statement

The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

Figures

FIGURE 1
FIGURE 1
Consensus chart of the individual transplant societies. Relevant key statements were deduced and formulated on the basis of information found on the individual transplantation society webpages. Categories were defined as (A) do support (green), (B) do not support (red), (C) leave the answer open/case‐by‐case decision (orange), or (D) do not comment (white). On the right‐hand side, the sum of supporting society recommendations was subtracted by dissenting votes and a final score was calculated. The final score was converted into a society recommendation consensus (SRC; “strong recommendation” = A, if more than 9 societies support the statement, >50%; “medium recommendation” = B, if 5‐9 societies support the statement, >25%; “low recommendation” = C, if 1‐4 societies support the statement, <25%). BAL, bronchoalveolar lavage; COVID, coronavirus disease 2019; CT, computed tomography; PCR, polymerase chain reaction; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.

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