Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands

Radiology. 2020 Oct;297(1):E216-E222. doi: 10.1148/radiol.2020201629. Epub 2020 Apr 23.

Abstract

A potential link between mortality, d-dimer values, and a prothrombotic syndrome has been reported in patients with coronavirus disease 2019 (COVID-19) infection. The National Institute for Public Health of the Netherlands asked a group of radiology and vascular medicine experts to provide guidance for the imaging work-up and treatment of these important complications. This report summarizes evidence for thromboembolic disease, potential diagnostic and preventive actions, and recommendations for prophylaxis and treatment of patients with COVID-19 infection.

MeSH terms

  • Adult
  • Betacoronavirus / isolation & purification
  • Coronavirus Infections / blood*
  • Coronavirus Infections / mortality
  • Coronavirus Infections / pathology
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / prevention & control
  • Disseminated Intravascular Coagulation / therapy
  • Disseminated Intravascular Coagulation / virology
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis
  • Humans
  • Lung / pathology
  • Male
  • Middle Aged
  • Netherlands / epidemiology
  • Pandemics
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / mortality
  • Pneumonia, Viral / pathology
  • Practice Guidelines as Topic
  • Public Health
  • Retrospective Studies
  • Thromboembolism / diagnosis
  • Thromboembolism / prevention & control
  • Thromboembolism / therapy*
  • Thromboembolism / virology*
  • Tomography, X-Ray Computed

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2