One year in review 2020: pathogenesis of rheumatoid arthritis

Clin Exp Rheumatol. 2020 May-Jun;38(3):387-397. doi: 10.55563/clinexprheumatol/3uj1ng. Epub 2020 Apr 23.


Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms and their association with disease susceptibility have added new elements to better clarify RA pathogenesis. In the last year, important elements have been added to the current knowledge of mechanisms regulating innate and adaptive immunity in RA, leading to discovering new targets for the development of disease-modifying therapies. Thus, in this review we summarise the new insights resulting from a literature research data published in the last year.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / pathology*
  • Genetic Predisposition to Disease
  • Humans
  • Immunity, Innate
  • Polymorphism, Genetic