COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

Immunity. 2020 May 19;52(5):731-733. doi: 10.1016/j.immuni.2020.04.003. Epub 2020 Apr 22.


Zhou et al. (Nature) and Hoffmann et al. (Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. These results may explain proinflammatory cytokine release via the associated angiotestin II pathway and a possible therapeutic target via the IL-6-STAT3 axis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Betacoronavirus
  • COVID-19
  • Chiroptera*
  • Coronavirus Infections
  • Coronavirus*
  • Cytokine Release Syndrome
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2
  • Virus Internalization