Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study

Nutrients. 2020 Apr 21;12(4):1159. doi: 10.3390/nu12041159.


Specific probiotic strains can alleviate the gastrointestinal (GI) symptoms and psychiatric comorbidities of irritable bowel syndrome (IBS). In this randomized, double-blind, placebo-controlled study, the efficacy of Lactobacillus paracasei HA-196 (L. paracasei) and Bifidobacterium longum R0175 (B. longum) in reducing the GI and psychological symptoms of IBS was evaluated in 251 adults with either constipation (IBS-C), diarrhea (IBS-D), or mixed-pattern (IBS-M). Following a 2-week run-in period, participants were randomized to one of three interventions: L. paracasei (n = 84), B. longum (n = 83) or placebo (n = 81). IBS symptoms, stool frequency and consistency and quality of life were assessed by questionnaires. The differences from baseline in the severity of IBS symptoms at 4 and 8 weeks were similar between groups. Participants in this study were classified, after randomization, into subtypes according to Rome III. Within the L. paracasei group, complete spontaneous and spontaneous bowel movement frequency increased in participants with IBS-C (n = 10) after 8 weeks of supplementation (both p < 0.05) and decreased in participants with IBS-D (n = 10, p = 0.013). Both L. paracasei and B. longum supplementation improved the quality of life in emotional well-being and social functioning compared with baseline (all p < 0.05). In conclusion, L. paracasei and B. longum may reduce GI symptom severity and improve the psychological well-being of individuals with certain IBS subtypes.

Keywords: Bifidobacterium longum; IBS; Irritable Bowel Syndrome; Lactobacillus paracasei; probiotics.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Bifidobacterium longum*
  • Dietary Supplements*
  • Double-Blind Method
  • Emotions
  • Female
  • Humans
  • Irritable Bowel Syndrome / psychology
  • Irritable Bowel Syndrome / therapy*
  • Lacticaseibacillus paracasei*
  • Male
  • Middle Aged
  • Probiotics / administration & dosage*
  • Quality of Life*
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Symptom Assessment / methods*
  • Treatment Outcome