Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;40(6):1316-1320.
doi: 10.1111/liv.14465. Epub 2020 Apr 24.

Coronavirus Disease 2019 and Prevalence of Chronic Liver Disease: A Meta-Analysis

Affiliations

Coronavirus Disease 2019 and Prevalence of Chronic Liver Disease: A Meta-Analysis

Alessandro Mantovani et al. Liver Int. .

Abstract

At present, there is scarce information regarding the global prevalence of chronic liver disease in individuals with coronavirus disease 2019 (COVID-19) disease, which is becoming a global pandemic. The aim of this study was to assess the overall prevalence of chronic liver disease among patients with COVID-19 disease by meta-analysing data in observational studies and to investigate the relationship between liver damage and COVID-19 disease. We included 11 observational studies for a total of 2034 adult individuals (median age 49 years [IQR 45-54], 57.2% men). The overall prevalence of chronic liver disease at baseline was 3% (95% CI 2%-4%; I2 = 29.1%). Individuals with severe COVID-19 disease had relevant alterations of liver enzymes and coagulative profile, probably due to the innate immune response against the virus. Further studies are needed to better investigate the causes of liver injury in patients with COVID-19 disease and the effect of treatment for COVID-19 on the liver.

Similar articles

See all similar articles

References

REFERENCES

    1. https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed March 26, 2020.
    1. Feng G, Zheng KI, Yan QQ, et al. COVID-19 and liver dysfunction: current insights and emergent therapeutic strategies. J Clin Transl Hepatol. 2020;8:1-7.
    1. Bangash MN, Patel J, Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol Hepatol. 2020. https://doi.org/10.1016/S2468-1253(20)30084-4
    1. Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020.5(5):428-430.
    1. Mo P, Xing Y, Xiao Y, et al. Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. Clin Infect Dis. 2020;ciaa270. https://doi.org/10.1093/cid/ciaa270

LinkOut - more resources

Feedback