Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2

Am J Respir Crit Care Med. 2020 Jun 15;201(12):1557-1559. doi: 10.1164/rccm.202003-0693LE.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / genetics
  • Betacoronavirus / metabolism
  • Coronavirus Infections
  • Databases, Genetic
  • European Continental Ancestry Group / genetics
  • Ex-Smokers
  • Furin / genetics*
  • Gene Expression Profiling
  • Humans
  • Lung / metabolism*
  • Non-Smokers
  • Pandemics
  • Peptidyl-Dipeptidase A / genetics*
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral
  • Pulmonary Disease, Chronic Obstructive / genetics
  • RNA-Seq
  • Serine Endopeptidases / genetics*
  • Smokers
  • Tobacco Smoking / genetics*
  • Up-Regulation

Substances

  • Peptidyl-Dipeptidase A
  • angiotensin converting enzyme 2
  • Serine Endopeptidases
  • TMPRSS2 protein, human
  • FURIN protein, human
  • Furin

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2