Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement

Ludger Klimek; Marek Jutel; Cezmi Akdis; Jean Bousquet; Mübeccel Akdis; Claus Bachert; Ioana Agache; Ignacio Ansotegui; Anna Bedbrook; Sinthia Bosnic-Anticevich; Giorgio W Canonica; Tomas Chivato; Alvaro A Cruz; Wienia Czarlewski; Stefano Del Giacco; Hui Du; Joao A Fonseca; Yadong Gao; Tari Haahtela; Karin Hoffmann-Sommergruber; Juan-Carlos Ivancevich; Nikolai Khaltaev; Edward F Knol; Piotr Kuna; Desiree Larenas-Linnemann; Erik Melen; Joaquim Mullol; Robert Naclerio; Ken Ohta; Yoshitaka Okamoto; Liam O'Mahony; Gabrielle L Onorato; Nikos G Papadopoulos; Ruby Pawankar; Oliver Pfaar; Boleslaw Samolinski; Jurgen Schwarze; Sanna Toppila-Salmi; Mohamed H Shamji; Maria Teresa Ventura; Arunas Valiulis; Arzu Yorgancioglu; Paolo Matricardi; Torsten Zuberbier; ARIA-MASK Study Group

doi:10.1111/all.14336

Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement

Allergy. 2020 Jul;75(7):1546-1554. doi: 10.1111/all.14336.

Authors

Ludger Klimek¹, Marek Jutel², Cezmi Akdis³, Jean Bousquet^{4

5

6

7}, Mübeccel Akdis³, Claus Bachert⁸, Ioana Agache⁹, Ignacio Ansotegui¹⁰, Anna Bedbrook⁶, Sinthia Bosnic-Anticevich¹¹, Giorgio W Canonica^{12

13}, Tomas Chivato^{14

15}, Alvaro A Cruz¹⁶, Wienia Czarlewski¹⁷, Stefano Del Giacco¹⁸, Hui Du¹⁹, Joao A Fonseca^{20

21}, Yadong Gao¹⁹, Tari Haahtela^{22

23

24

25}, Karin Hoffmann-Sommergruber²⁶, Juan-Carlos Ivancevich²⁷, Nikolai Khaltaev²⁸, Edward F Knol²⁹, Piotr Kuna³⁰, Desiree Larenas-Linnemann³¹, Erik Melen³², Joaquim Mullol^{33

34}, Robert Naclerio³⁵, Ken Ohta³⁶, Yoshitaka Okamoto³⁷, Liam O'Mahony³⁸, Gabrielle L Onorato⁶, Nikos G Papadopoulos³⁹, Ruby Pawankar⁴⁰, Oliver Pfaar⁴¹, Boleslaw Samolinski⁴², Jurgen Schwarze⁴³, Sanna Toppila-Salmi^{21

22

23

24}, Mohamed H Shamji⁴⁴, Maria Teresa Ventura^{45

46}, Arunas Valiulis⁴⁷, Arzu Yorgancioglu^{48

49}, Paolo Matricardi⁵⁰, Torsten Zuberbier^{51

52}; ARIA-MASK Study Group

Affiliations

¹ Center for Rhinology and Allergology, Wiesbaden, Germany.
² Department of Clinical Immunology, Wrocław Medical University, ALL-MED Medical Research Institute, Wrocław, Poland.
³ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
⁴ Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany.
⁵ University Hospital Montpellier, Montpellier, France.
⁶ MACVIA-France, Montpellier, France.
⁷ Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium.
⁸ Transylvania University Brasov, Brasov, Romania.
⁹ Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia, Erandio, Spain.
¹⁰ Woolcock Institute of Medical Research, University of Sydney, Woolcock Emphysema Centre, Sydney Local Health District, Glebe, NSW, Australia.
¹¹ Personalized Medicine, Asthma and Allergy - Humanitas Clinical and Research Center IRCCS, Rozzano, MI, Italy.
¹² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
¹³ School of Medicine, University CEU San Pablo, Madrid, Spain.
¹⁴ ProAR - Nucleo de Excelencia em Asma, Federal University of Bahia, Bahia, Brazil.
¹⁵ WHO GARD Planning Group, Bahia, Brazil.
¹⁶ Medical Consulting Czarlewski, Levallois, and MASK-air, Montpellier, France.
¹⁷ Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.
¹⁸ Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong, China.
¹⁹ University of Science and Technology, Wuhan, China.
²⁰ Center for Research in Health Technologies and Information Systems- CINTESIS, Universidade do Porto, Porto, Portugal.
²¹ Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal.
²² Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
²³ Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
²⁴ Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
²⁵ Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
²⁶ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
²⁷ GARD Chairman, Geneva, Switzerland.
²⁸ Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
²⁹ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
³⁰ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
³¹ Institute of Environmental Medicine, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.
³² Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain.
³³ Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
³⁴ Johns Hopkins School of Medicine, Baltimore, MD, USA.
³⁵ National Hospital Organization, Tokyo National Hospital, Tokyo, Japan.
³⁶ Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan.
³⁷ Departments of Medicine and Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.
³⁸ Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital,, University of Manchester, Manchester, UK.
³⁹ Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
⁴⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität Marburg, Marburg, Germany.
⁴¹ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität Marburg, Germany.
⁴² Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
⁴³ Centre for Inflammation Research, Child Life and Health, The University of Edinburgh, Edinburgh, UK.
⁴⁴ Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
⁴⁵ Vilnius University Faculty of Medicine, Institute of Clinical Medicine & Institute of Health Sciences, Vilnius, Lithuania.
⁴⁶ European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium.
⁴⁷ Department of Pulmonology, Celal Bayar University, Manisa, Turkey.
⁴⁸ Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁴⁹ Department of Dermatology and Allergy, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Comprehensive Allergy-Centre, Berlin, Germany.
⁵⁰ Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
⁵¹ Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
⁵² Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Abstract

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Keywords: allergy treatment; immunotherapy clinical; immunotherapy vaccines and mechanisms.

MeSH terms

Allergists / psychology
Asthma / complications
Asthma / therapy*
Betacoronavirus / genetics*
Betacoronavirus / immunology*
CD8-Positive T-Lymphocytes / immunology
COVID-19
Coronavirus Infections / complications
Coronavirus Infections / immunology*
Coronavirus Infections / prevention & control*
Coronavirus Infections / virology
Eosinophils / immunology
Humans
Immunoglobulin E / metabolism
Immunoglobulin M / metabolism
Infection Control / methods*
Pandemics / prevention & control*
Pneumonia, Viral / complications
Pneumonia, Viral / immunology*
Pneumonia, Viral / prevention & control*
Pneumonia, Viral / virology
Rhinitis, Allergic / complications
Rhinitis, Allergic / therapy*
SARS-CoV-2
Sublingual Immunotherapy / methods*
Th2 Cells / immunology

Substances

Immunoglobulin M
Immunoglobulin E