A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair

Huifang Yuan; Xiaoyan Zheng; Wan Liu; Hui Zhang; Jingjing Shao; Jiaxin Yao; Chunyi Mao; Junfeng Hui; Daidi Fan

doi:10.1016/j.colsurfb.2020.111041

A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair

Colloids Surf B Biointerfaces. 2020 Apr 18:192:111041. doi: 10.1016/j.colsurfb.2020.111041. Online ahead of print.

Authors

Huifang Yuan¹, Xiaoyan Zheng¹, Wan Liu¹, Hui Zhang¹, Jingjing Shao¹, Jiaxin Yao¹, Chunyi Mao², Junfeng Hui³, Daidi Fan⁴

Affiliations

¹ Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China; Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China; School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China.
² School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China.
³ Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China; Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China; School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China. Electronic address: huijunfeng@126.com.
⁴ Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China; Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China; School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi, 710069, China. Electronic address: fandaidi@nwu.edu.cn.

PMID: 32330818
DOI: 10.1016/j.colsurfb.2020.111041

Abstract

Cartilage tissue engineering has become the trend of cartilage defect repair owing to the engineered biomimetic tissue that can mimic the structural, biological and functional characteristics of natural cartilage. Biomaterials with high biocompatibility and regeneration capacity are expected to be used in cartilage tissue engineering. Herein, in this study, a dual-network bovine serum albumin/sodium alginate with hydroxyapatite nanowires composite (B-S-H) hydrogel scaffold has been prepared for cartilage repair. The obtained B-S-H hydrogel scaffold exhibits ideal physical properties, such as excellent mechanical strength, high porosity and swelling ratio, as well as the excellent biological activity to promote the human bone marrow derived mesenchymal stem cells (hBMSCs) proliferation and differentiation. The in vivo study further shows that the B-S -H hydrogel scaffold can obviously promote the generation of new cartilage that integrates well with surrounding tissues and is similar to adjacent cartilage in terms of thickness. It is considered that the B-S-H hydrogel scaffold has great potential in the application of cartilage defects repair.

Keywords: Bovine serum albumin; Cartilage repair; Hydrogel scaffold; Hydroxyapatite nanowires.