Current Clinical Trials for Tinnitus: Drugs and Biologics

Otolaryngol Clin North Am. 2020 Aug;53(4):651-666. doi: 10.1016/j.otc.2020.03.012. Epub 2020 Apr 23.

Abstract

Despite recent, major steps forward in our understanding of tinnitus pathophysiology and improved research methodology, tinnitus remains a clear unmet clinical need. Here, the authors identify current active clinical and preclinical development programs of tinnitus drug candidates using publications, databases, and company communications. The current drug development programs hold promise for new therapeutic options for tinnitus patients, but further fundamental research is needed to validate additional targets for treating tinnitus.

Keywords: Calcium; Clinical trials; Glutamate; Hearing loss; NMDA; Potassium; Preclinical development; Tinnitus.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products / therapeutic use
  • Clinical Trials as Topic
  • Disease Models, Animal
  • Humans
  • Tinnitus / drug therapy*
  • Tinnitus / physiopathology
  • Translational Research, Biomedical

Substances

  • Biological Products