The primary tumor resection in patients with distant metastatic laryngeal carcinoma

Eur Arch Otorhinolaryngol. 2020 Oct;277(10):2859-2868. doi: 10.1007/s00405-020-05987-9. Epub 2020 Apr 25.


Background: The role of primary tumor resection in patients with distant metastatic laryngeal carcinoma (DMLC) has not been clarified completely. Thus, we used propensity score matching (PSM) and survival analysis to address this issue.

Methods: The PSM was utilized to avoid selection bias and disproportionate distributions of the confounding factors. Kaplan-Meier estimates and Cox proportional hazard analysis were utilized to evaluate overall survival (OS) and cancer-specific survival (CSS).

Results: From the Surveillance, Epidemiology, and End Results Program database, a cohort of 480 patients with DMLC were included. After PSM, the OS and CSS for patients who underwent resection were significantly longer than those without resection (median OS: 19 months vs. 8 months, P < 0.001; median CSS: 19 months vs. 9 months, P = 0.002). Tumor resection significantly prolonged survival of DMLC patients with appropriate demographic and clinical characteristics. In the multivariate analysis, age at diagnosis, race, pathologic subtype, and marital status were found significantly affecting both OS and CSS of patients who underwent surgical resection. Predictive nomograms were developed to help distinguish patients with early mortality potential after surgical resection.

Conclusions: This study is the first one using PSM to assess the role played by surgical resection in DMLC and evaluate the prognostic factor of resected patients. Premised on well controlled postoperative complications, resection could significantly prolong OS and CSS of certain patients.

Keywords: Distant metastatic; Laryngeal carcinoma; Primary tumor resection; Propensity score matching; SEER database.

MeSH terms

  • Carcinoma*
  • Humans
  • Kaplan-Meier Estimate
  • Nomograms*
  • Propensity Score
  • SEER Program