Blastic Plasmacytoid Dendritic Cell Neoplasm: The Dermatologist's Perspective

Hematol Oncol Clin North Am. 2020 Jun;34(3):501-509. doi: 10.1016/j.hoc.2020.01.001. Epub 2020 Mar 20.


Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive malignancy derived from the plasmacytoid dendritic cell that commonly involves the skin. Cutaneous involvement is often the initial presentation, with deep purple or red-brown macules, plaques, or tumors. As such, dermatologists may be the first to see these patients and, in addition to oncologists, should be familiar with its presentation to facilitate early diagnosis, helping to distinguish it from acute myelogenous leukemia cutis.

Keywords: BPDCN; Blastic natural-killer cell lymphoma; Blastic plasmacytoid dendritic cell neoplasm; CD4(+)CD56(+) hematodermic neoplasm.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Dendritic Cells / pathology*
  • Diagnosis, Differential
  • Disease Management
  • Humans
  • Myeloproliferative Disorders / diagnosis*
  • Myeloproliferative Disorders / etiology
  • Myeloproliferative Disorders / metabolism
  • Myeloproliferative Disorders / therapy
  • Prognosis
  • Skin / pathology*
  • Skin Neoplasms / diagnosis
  • Symptom Assessment