Treatment of SARS-CoV-2: How Far Have We Reached?

Drug Discov Ther. 2020 May 6;14(2):67-72. doi: 10.5582/ddt.2020.03008. Epub 2020 Apr 25.

Abstract

The virus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is currently affecting more than 200 countries and territories worldwide. It has been declared as pandemic by World Health Organization (WHO) and the whole world is suffering from corona virus disease 2019 (COVID-19). Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field.

Keywords: SARS-CoV-2; antiviral; clinical trial; corona virus; pandemic.

Publication types

  • Review

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / therapeutic use
  • Alanine / analogs & derivatives
  • Alanine / therapeutic use
  • Amides / therapeutic use
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Antiviral Agents / therapeutic use*
  • Betacoronavirus
  • Chloroquine / therapeutic use
  • Clinical Trials as Topic
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / therapy*
  • Darunavir / therapeutic use
  • Drug Combinations
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Immunization, Passive
  • Indoles / therapeutic use
  • Interferon-alpha / therapeutic use
  • Interferon-beta / therapeutic use
  • Lopinavir / therapeutic use
  • Pandemics
  • Pneumonia, Viral / therapy*
  • Pyrazines / therapeutic use
  • Ritonavir / therapeutic use

Substances

  • Amides
  • Antibodies, Monoclonal, Humanized
  • Antiviral Agents
  • Drug Combinations
  • Indoles
  • Interferon-alpha
  • Pyrazines
  • lopinavir-ritonavir drug combination
  • Lopinavir
  • remdesivir
  • Adenosine Monophosphate
  • Hydroxychloroquine
  • Interferon-beta
  • Chloroquine
  • arbidol
  • favipiravir
  • sarilumab
  • Ritonavir
  • Alanine
  • Darunavir

Supplementary concepts

  • COVID-19
  • COVID-19 drug treatment
  • COVID-19 serotherapy
  • severe acute respiratory syndrome coronavirus 2