Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis

ERJ Open Res. 2020 Apr 19;6(2):00318-2019. doi: 10.1183/23120541.00318-2019. eCollection 2020 Apr.


This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-γ http://bit.ly/2TeI6LG.