Although the field of natural product extraction with ionic liquids (ILs) is already a crowded one, the guiding rules regarding the selection of suitable ILs for extraction are still lacking. In this study, the extraction capacity of 32 ILs was investigated using Puerariae lobatae as a testing material, namely, 11 [BMIM]-based, 9 [CMIM]-based, 8 [C n MIM][Br] and 8 [C n MIM][BF4] ILs (n = 2, 4, 6, 8, 10, 12, 14, 16) were studied. Three series of concentrations (0.02, 0.50, 2.00 M) were investigated, and the results demonstrated that the extraction capacity increased with the rising IL concentrations except for 1-butyl-3-methyl-imidazolium tosylate ([BMIM][Tos]). Generally, all the 0.50 and 2.00 M ILs led to the best extraction results. At low concentrations, the IL extraction capacity is strongly dependent on the anions and cations. However, the relationship between extraction capacity and anions or cations gradually becomes weak as increasing IL concentrations. Finally, the solution of ILs was prepared in aqueous or 60% methanol depending on the solubility. The pH can vary from strong acid to weak alkaline. Extraction capacity of 32 ILs varying in concentrations has a good negative correlation with the pH, except for five [BMIM]-ILs.
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