Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

Nan Zhang; Di Liu; Shuxiang Wei; Shijie Cao; Xinchi Feng; Kai Wang; Liqin Ding; Feng Qiu

doi:10.1186/s13065-020-00685-3

Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

BMC Chem. 2020 Apr 22;14(1):31. doi: 10.1186/s13065-020-00685-3. eCollection 2020 Dec.

Authors

Nan Zhang^#^{1

2}, Di Liu^#^{1

2}, Shuxiang Wei^{1

2}, Shijie Cao^{1

2}, Xinchi Feng¹, Kai Wang¹, Liqin Ding^{1

2}, Feng Qiu^{1

2}

Affiliations

¹ 1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai Dist, Tianjin, 301617 People's Republic of China.
² 2Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

^# Contributed equally.

Abstract

Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl₂-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity.

Keywords: Aesculus chinensis Bge. var. chekiangensis (Hu et Fang) Fang; Neuroprotective activity; Phenylethanol glycosides.