Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, and TPH2-703G/T (rs4570625) genotype

Acta Neuropsychiatr. 2020 Oct;32(5):247-256. doi: 10.1017/neu.2020.18. Epub 2020 Apr 27.

Abstract

Objective: Reward sensitivity is an increasingly used construct in psychiatry, yet its possible inner structure and relationship with other affective variables are not well known.

Methods: A reward sensitivity measurement scale was constructed on the basis of large item pool collected from birth cohort representative samples (the Estonian Children Personality Behaviour and Health Study; original n = 1238). Affective Neuroscience Personality Scale (ANPS) and the Adult Attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS) were administered in young adulthood. A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped.

Results: Reward sensitivity consisted of two orthogonal components, operationally defined as Openness to Rewards and Insatiability by Reward, that respectively characterise the striving towards multiple rewards and the strong pursuit and fixation to a particular reward. While SEEKING and PLAY (and to lower extent CARE) of the ANPS co-varied with Openness to Rewards, FEAR, SADNESS, and ANGER were related to Insatiability by Reward. The total score of ASRS was moderately correlated with Insatiability by Reward, while the association with Openness to Rewards was negligible. However, ASRS Inattention had some negative relationship with the Social Experience facet of Openness to Rewards. The T/T homozygotes for the TPH2 promoter polymorphism had lower Insatiability by Reward but not Openness to Rewards.

Conclusions: Behaviours sensitive to rewards are separable to the components of variability and fixation, and these components are differentially related to affective aspects of personality, attention, and hyperactivity as well as to TPH2 genotype.

Keywords: attention-deficit hyperactivity disorder; emotions; reward; serotonin; tryptophan hydroxylase.

Publication types

  • Comparative Study

MeSH terms

  • Attention Deficit Disorder with Hyperactivity / genetics
  • Attention Deficit Disorder with Hyperactivity / psychology*
  • Emotions / physiology*
  • Estonia / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Homozygote
  • Humans
  • Male
  • Personality Disorders / psychology*
  • Personality Tests / standards
  • Polymorphism, Single Nucleotide / genetics
  • Reward
  • Serotonin / metabolism
  • Tryptophan Hydroxylase / genetics*
  • Tryptophan Hydroxylase / metabolism
  • Young Adult

Substances

  • Serotonin
  • TPH2 protein, human
  • Tryptophan Hydroxylase