Reflux Disease and Laryngeal Neoplasia in Nonsmokers and Nondrinkers

Otolaryngol Head Neck Surg. 2020 Sep;163(3):560-562. doi: 10.1177/0194599820917669. Epub 2020 Apr 28.


Gastroesophageal reflux disease (GERD) has been hypothesized as a risk factor for development of laryngeal cancer. A case-control study was performed to assess the association of laryngeal neoplasia with GERD. Cases consisted of patients with a history of laryngeal cancer or carcinoma in situ. Controls were patients without neoplasia who matched cases 2:1 on age, sex, race, and smoking history. Univariate and multivariate analyses were performed to assess risk of laryngeal neoplasia and GERD. In total, 2094 patients were included. Cases had higher rates of GERD. Univariate analysis demonstrated a positive association between GERD and laryngeal neoplasia (odds ratio, 1.33; 95% CI, 1.07-1.64). Multivariate analysis controlling for alcohol use history also demonstrated a positive association between GERD and laryngeal neoplasia (adjusted odds ratio, 1.29; 95% CI, 1.04-1.59). These results suggest increased odds of laryngeal carcinoma and carcinoma in situ in patients with GERD when controlling for smoking and drinking history.

Keywords: gastroesophageal reflux disease; head and neck cancer; laryngeal cancer; pathogenesis.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alcohol Drinking*
  • Carcinoma in Situ / epidemiology
  • Carcinoma in Situ / pathology
  • Carcinoma in Situ / psychology*
  • Case-Control Studies
  • Female
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / pathology
  • Gastroesophageal Reflux / psychology
  • Humans
  • Laryngeal Neoplasms / epidemiology*
  • Laryngeal Neoplasms / pathology
  • Laryngeal Neoplasms / psychology*
  • Male
  • Middle Aged
  • Odds Ratio
  • Smoking*