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. 2020 May;13(5):667-673.
doi: 10.1016/j.jiph.2020.03.019. Epub 2020 Apr 8.

Coronavirus Disease 2019 (COVID-19): A Literature Review

Free PMC article

Coronavirus Disease 2019 (COVID-19): A Literature Review

Harapan Harapan et al. J Infect Public Health. .
Free PMC article


In early December 2019, an outbreak of coronavirus disease 2019 (COVID-19), caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan City, Hubei Province, China. On January 30, 2020 the World Health Organization declared the outbreak as a Public Health Emergency of International Concern. As of February 14, 2020, 49,053 laboratory-confirmed and 1,381 deaths have been reported globally. Perceived risk of acquiring disease has led many governments to institute a variety of control measures. We conducted a literature review of publicly available information to summarize knowledge about the pathogen and the current epidemic. In this literature review, the causative agent, pathogenesis and immune responses, epidemiology, diagnosis, treatment and management of the disease, control and preventions strategies are all reviewed.

Keywords: 2019-nCoV; COVID-19; Novel coronavirus; Outbreak; SARS-CoV-2.

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    1. Lu H., Stratton C.W., Tang Y.W. Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle. J Med Virol. 2020 - PMC - PubMed
    1. Hui D.S., E I.A., Madani T.A., Ntoumi F., Kock R., Dar O. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264–266. - PMC - PubMed
    1. Gorbalenya A.E.A. Severe acute respiratory syndrome-related coronavirus: the species and its viruses – a statement of the Coronavirus Study Group. BioRxiv. 2020 doi: 10.1101/2020.02.07.937862. - DOI
    1. Burki T.K. Coronavirus in China. Lancet Respir Med. 2020 - PMC - PubMed
    1. NHS press conference, February 4, 2020. Beijing, China. National Health Commission (NHC) of the People's Republic of China.

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