Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy

doi:10.1038/s41571-020-0375-1

. 2020 Jun;17(6):332-334.

doi: 10.1038/s41571-020-0375-1.

Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy

Himanshu Nagar¹, Silvia C Formenti²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
² Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA. formenti@med.cornell.edu.

PMID: 32341524
PMCID: PMC7184542
DOI: 10.1038/s41571-020-0375-1

Free PMC article

Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy

Himanshu Nagar et al. Nat Rev Clin Oncol. 2020 Jun.

Free PMC article

. 2020 Jun;17(6):332-334.

doi: 10.1038/s41571-020-0375-1.

Authors

Himanshu Nagar¹, Silvia C Formenti²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
² Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA. formenti@med.cornell.edu.

PMID: 32341524
PMCID: PMC7184542
DOI: 10.1038/s41571-020-0375-1

Abstract

Radiotherapy can be safely delivered during the coronavirus disease 2019 (COVID-19) pandemic, often through use of hypofractionated regimens, which minimize the number of visits to treatment centres while also avoiding potentially detrimental delays in the delivery of cancer care.

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Conflict of interest statement

S.C.F. declares funding for clinical trials from Bristol Myers Squibb, Merck and Varian, speaker and/or advisory honoraria from Astra Zeneca, Bayer, Bristol Myers Squibb, Eisai, Elekta, EMD Serono/Merck, GlaxoSmithKline, Janssen, MedImmune, Merck US, Regeneron, Varian, ViewRay. All interests declared are not directly related to this manuscript. H.N. declares no competing interests.

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References

1. Wild AT, et al. Lymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2016;94:571–579. doi: 10.1016/j.ijrobp.2015.11.026. - DOI - PMC - PubMed
1. Lipsitch M, Swerdlow DL, Finelli L. Defining the epidemiology of Covid-19 - studies needed. N. Engl. J. Med. 2020;382:1194–1196. doi: 10.1056/NEJMp2002125. - DOI - PubMed
1. Huang J, Barbera L, Brouwers M, Browman G, Mackillop WJ. Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J. Clin. Oncol. 2003;21:555–563. doi: 10.1200/JCO.2003.04.171. - DOI - PubMed
1. Darby S, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–1716. doi: 10.1016/S0140-6736(11)61629-2. - DOI - PMC - PubMed
1. Lanciano RM, Pajak TF, Martz K, Hanks GE. The influence of treatment time on outcome for squamous cell cancer of the uterine cervix treated with radiation: a patterns-of-care study. Int. J. Radiat. Oncol. Biol. Phys. 1993;25:391–397. doi: 10.1016/0360-3016(93)90058-4. - DOI - PubMed

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[1] Wild AT, et al. Lymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2016;94:571–579. doi: 10.1016/j.ijrobp.2015.11.026. - DOI - PMC - PubMed

[2] Wild AT, et al. Lymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2016;94:571–579. doi: 10.1016/j.ijrobp.2015.11.026. - DOI - PMC - PubMed

[3] Lipsitch M, Swerdlow DL, Finelli L. Defining the epidemiology of Covid-19 - studies needed. N. Engl. J. Med. 2020;382:1194–1196. doi: 10.1056/NEJMp2002125. - DOI - PubMed

[4] Lipsitch M, Swerdlow DL, Finelli L. Defining the epidemiology of Covid-19 - studies needed. N. Engl. J. Med. 2020;382:1194–1196. doi: 10.1056/NEJMp2002125. - DOI - PubMed

[5] Huang J, Barbera L, Brouwers M, Browman G, Mackillop WJ. Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J. Clin. Oncol. 2003;21:555–563. doi: 10.1200/JCO.2003.04.171. - DOI - PubMed

[6] Huang J, Barbera L, Brouwers M, Browman G, Mackillop WJ. Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J. Clin. Oncol. 2003;21:555–563. doi: 10.1200/JCO.2003.04.171. - DOI - PubMed

[7] Darby S, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–1716. doi: 10.1016/S0140-6736(11)61629-2. - DOI - PMC - PubMed

[8] Darby S, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–1716. doi: 10.1016/S0140-6736(11)61629-2. - DOI - PMC - PubMed

[9] Lanciano RM, Pajak TF, Martz K, Hanks GE. The influence of treatment time on outcome for squamous cell cancer of the uterine cervix treated with radiation: a patterns-of-care study. Int. J. Radiat. Oncol. Biol. Phys. 1993;25:391–397. doi: 10.1016/0360-3016(93)90058-4. - DOI - PubMed

[10] Lanciano RM, Pajak TF, Martz K, Hanks GE. The influence of treatment time on outcome for squamous cell cancer of the uterine cervix treated with radiation: a patterns-of-care study. Int. J. Radiat. Oncol. Biol. Phys. 1993;25:391–397. doi: 10.1016/0360-3016(93)90058-4. - DOI - PubMed

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Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy

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Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy

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Abstract

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