Exercise and Muscle Atrophy

Adv Exp Med Biol. 2020;1228:255-267. doi: 10.1007/978-981-15-1792-1_17.


The incidence of muscle atrophy is increasing with each passing year, which imposes a huge burden on the quality of life of patients. It is a public health issue that causes a growing concern around the world. Exercise is one of the key strategies to prevent and treat various diseases. Appropriate exercise is conducive to compensatory muscle hypertrophy, to improve muscle strength and elasticity, and to train muscle coordination, which is also beneficial to the recovery of skeletal muscle function and the regeneration of muscle cells. Sequelae of paralysis of patients with limb dyskinesia caused by muscle atrophy will be significantly alleviated after regular exercise therapy. Furthermore, exercise therapy can slow down or even reverse muscle atrophy. This article aims to introduce the characteristics of muscle atrophy and summarize the role and mechanism of exercise in the treatment of muscle atrophy in the existing studies, in order to further explore the mechanism of exercise to protect muscle atrophy and provide protection for patients with muscular atrophy.

Keywords: Atrophy; Exercise; Muscle; Strength.

Publication types

  • Review

MeSH terms

  • Exercise*
  • Humans
  • Muscle Strength
  • Muscle, Skeletal / pathology
  • Muscle, Skeletal / physiopathology
  • Muscular Atrophy* / pathology
  • Muscular Atrophy* / physiopathology
  • Muscular Atrophy* / prevention & control
  • Muscular Atrophy* / therapy
  • Quality of Life