Case Report: Viral Shedding for 60 Days in a Woman with COVID-19

Am J Trop Med Hyg. 2020 Jun;102(6):1210-1213. doi: 10.4269/ajtmh.20-0275.

Abstract

Novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a public health emergency of international concern. This was first noted in Wuhan, Hubei Province, China, and since then has become widespread globally. We report a 71-year-old woman with documented viral shedding (based on reverse transcription-polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 60 days from the onset of symptoms (55 days from her first positive test and 36 days after complete resolution of symptoms). This is to our knowledge the longest duration of viral shedding reported to date. This case demonstrates that viral shedding after COVID-19 diagnosis can be prolonged.

Publication types

  • Case Reports

MeSH terms

  • Acids, Carbocyclic
  • Aged
  • Betacoronavirus / drug effects
  • Betacoronavirus / isolation & purification
  • Betacoronavirus / pathogenicity*
  • COVID-19
  • China
  • Coronavirus Infections / diagnostic imaging*
  • Coronavirus Infections / immunology
  • Coronavirus Infections / pathology
  • Coronavirus Infections / therapy
  • Cyclopentanes / therapeutic use
  • Extracorporeal Membrane Oxygenation
  • Female
  • Guanidines / therapeutic use
  • Humans
  • Indoles / therapeutic use
  • Lung / diagnostic imaging*
  • Lung / drug effects
  • Lung / pathology
  • Lung / virology
  • Moxifloxacin / therapeutic use
  • Pandemics
  • Pneumonia, Viral / diagnostic imaging*
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / therapy
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Virus Shedding*

Substances

  • Acids, Carbocyclic
  • Cyclopentanes
  • Guanidines
  • Indoles
  • umifenovir
  • peramivir
  • Moxifloxacin