CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes

Genome Biol. 2020 Apr 28;21(1):101. doi: 10.1186/s13059-020-02018-y.


Existing circular RNA (circRNA) databases have become essential for transcriptomics. However, most are unsuitable for mining in-depth information for candidate circRNA prioritization. To address this, we integrate circular transcript collections to develop the circAtlas database based on 1070 RNA-seq samples collected from 19 normal tissues across six vertebrate species. This database contains 1,007,087 highly reliable circRNAs, of which over 81.3% have been assembled into full-length sequences. We profile their expression pattern, conservation, and functional annotation. We describe a novel multiple conservation score, co-expression, and regulatory networks for circRNA annotation and prioritization. CircAtlas can be accessed at

Keywords: Functional prioritization; Multiple conservation score; circAtlas; circRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Conserved Sequence
  • Databases, Nucleic Acid*
  • Humans
  • Mice
  • Molecular Sequence Annotation
  • RNA, Circular / chemistry
  • RNA, Circular / genetics
  • RNA, Circular / metabolism*
  • RNA-Binding Proteins / metabolism
  • RNA-Seq
  • Rats
  • Transcriptome*
  • Vertebrates / genetics
  • Vertebrates / metabolism


  • RNA, Circular
  • RNA-Binding Proteins