Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues

Alisdair R Fernie; Youjun Zhang; Arun Sampathkumar

doi:10.1016/j.tibs.2020.04.003

Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues

Trends Biochem Sci. 2020 Aug;45(8):637-638. doi: 10.1016/j.tibs.2020.04.003. Epub 2020 Apr 25.

Authors

Alisdair R Fernie¹, Youjun Zhang², Arun Sampathkumar³

Affiliations

¹ Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria. Electronic address: fernie@mpimp-golm.mpg.de.
² Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
³ Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.

PMID: 32345468
DOI: 10.1016/j.tibs.2020.04.003

Abstract

Energy-demanding processes, such as cell growth, migration, and differentiation, are tension modulated, begging the question whether metabolism and mechanical tension are tightly linked. A recent report by Park et al. shows that stiffness in the extracellular matrix (ECM) promotes reorganization of actin, resulting in enhanced glycolysis.

Keywords: E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21); F-actin bundling; PFK degradation; cancer; glycolytic regulation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Actins / metabolism
Cues*
Cytoskeleton* / metabolism
Extracellular Matrix / metabolism
Glycolysis

Substances

Actins