COVID-19: towards understanding of pathogenesis

doi:10.1038/s41422-020-0327-4

Comment

. 2020 May;30(5):367-369.

doi: 10.1038/s41422-020-0327-4.

COVID-19: towards understanding of pathogenesis

Wei Cao¹, Taisheng Li²

Affiliations

¹ Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1# Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China.
² Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1# Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China. litsh@263.net.

PMID: 32346073
PMCID: PMC7186532
DOI: 10.1038/s41422-020-0327-4

Free PMC article

Comment

COVID-19: towards understanding of pathogenesis

Wei Cao et al. Cell Res. 2020 May.

Free PMC article

. 2020 May;30(5):367-369.

doi: 10.1038/s41422-020-0327-4.

Authors

Wei Cao¹, Taisheng Li²

Affiliations

¹ Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1# Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China.
² Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1# Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China. litsh@263.net.

PMID: 32346073
PMCID: PMC7186532
DOI: 10.1038/s41422-020-0327-4

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1. Hypothetical pathogenesis of COVID-19.**
The X-axis refers to days after SARS-CoV-2 infection. The disease course is divided into three phases. The Y-axis shows the trend of T cells, B cells, inflammatory factors, D-dimer and viral load in patients. a The trend of each indicator in severe COVID-19 patients. b The trend of each indicator in severe COVID-19 patients after low-molecular-weight heparin (LWMH) and high-dose intravenous immunoglobulin (IVIg) therapy. The shaded areas represent the recommended intervention time for LMWH and IVIg treatment.

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References

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[1] Lu R, et al. Lancet. 2020;395:565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed

[2] Lu R, et al. Lancet. 2020;395:565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed

[3] Wölfel, R. et al. Nature10.1038/s41586-020-2196-x (2020). - PubMed

[4] Wölfel, R. et al. Nature10.1038/s41586-020-2196-x (2020). - PubMed

[5] Qin, C. et al. Clin. Infect. Dis. 10.1093/cid/ciaa248 (2020). - PubMed

[6] Qin, C. et al. Clin. Infect. Dis. 10.1093/cid/ciaa248 (2020). - PubMed

[7] Zhou F, et al. Lancet. 2020;395:1054–1062. doi: 10.1016/S0140-6736(20)30566-3. - DOI - PMC - PubMed

[8] Zhou F, et al. Lancet. 2020;395:1054–1062. doi: 10.1016/S0140-6736(20)30566-3. - DOI - PMC - PubMed

[9] Xu Z, et al. Lancet Respir. Med. 2020;8:420–422. doi: 10.1016/S2213-2600(20)30076-X. - DOI - PMC - PubMed

[10] Xu Z, et al. Lancet Respir. Med. 2020;8:420–422. doi: 10.1016/S2213-2600(20)30076-X. - DOI - PMC - PubMed

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COVID-19: towards understanding of pathogenesis

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