Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety

doi:10.1093/ehjcvp/pvaa041

Comment

. 2020 Jul 1;6(4):256-257.

doi: 10.1093/ehjcvp/pvaa041.

Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety

Kamalan Jeevaratnam^{1

2}

Affiliations

¹ Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.
² Physiological Laboratory, University of Cambridge, Cambridge, UK.

PMID: 32347923
PMCID: PMC7197554
DOI: 10.1093/ehjcvp/pvaa041

Comment

Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety

Kamalan Jeevaratnam. Eur Heart J Cardiovasc Pharmacother. 2020.

. 2020 Jul 1;6(4):256-257.

doi: 10.1093/ehjcvp/pvaa041.

Author

Kamalan Jeevaratnam^{1

2}

Affiliations

¹ Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.
² Physiological Laboratory, University of Cambridge, Cambridge, UK.

PMID: 32347923
PMCID: PMC7197554
DOI: 10.1093/ehjcvp/pvaa041

No abstract available

PubMed Disclaimer

Comment on

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G. Wang M, et al. Cell Res. 2020 Mar;30(3):269-271. doi: 10.1038/s41422-020-0282-0. Epub 2020 Feb 4. Cell Res. 2020. PMID: 32020029 Free PMC article. No abstract available.
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.
Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, Li Y, Hu Z, Zhong W, Wang M. Liu J, et al. Cell Discov. 2020 Mar 18;6:16. doi: 10.1038/s41421-020-0156-0. eCollection 2020. Cell Discov. 2020. PMID: 32194981 Free PMC article. No abstract available.

Cited by

Concentration-dependent mortality of chloroquine in overdose.
Watson JA, Tarning J, Hoglund RM, Baud FJ, Megarbane B, Clemessy JL, White NJ. Watson JA, et al. Elife. 2020 Jul 8;9:e58631. doi: 10.7554/eLife.58631. Elife. 2020. PMID: 32639233 Free PMC article.
How to overcome cardiovascular challenges in COVID-19 patients: a guide for common practice.
Eslami P, Tabary M, Dooghaie-Moghadam A, Khaheshi I. Eslami P, et al. Acta Biomed. 2020 Sep 7;91(3):e2020021. doi: 10.23750/abm.v91i3.9848. Acta Biomed. 2020. PMID: 32921718 Free PMC article. Review.
Emerging Prevention and Treatment Strategies to Control COVID-19.
Singh VK, Mishra A, Singh S, Kumar P, Singh M, Jagannath C, Khan A. Singh VK, et al. Pathogens. 2020 Jun 23;9(6):501. doi: 10.3390/pathogens9060501. Pathogens. 2020. PMID: 32585805 Free PMC article. Review.
Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?
Chadda KR, Blakey EE, Huang CL, Jeevaratnam K. Chadda KR, et al. Front Cardiovasc Med. 2022 Mar 9;9:860198. doi: 10.3389/fcvm.2022.860198. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35355961 Free PMC article. Review.
Adverse Effects Associated With the Use of Antimalarials During The COVID-19 Pandemic in a Tertiary Care Center in Mexico City.
Lozano-Cruz OA, Jiménez JV, Olivas-Martinez A, Ortiz-Brizuela E, Cárdenas-Fragoso JL, Azamar-Llamas D, Rodríguez-Rodríguez S, Oseguera-Moguel JC, Dorantes-García J, Barrón-Magdaleno C, Cázares-Diazleal AC, Román-Montes CM, Tamez-Torres KM, Martínez-Guerra BA, Gulias-Herrero A, González-Lara MF, Ponce-de-León-Garduño A, Kershenobich-Stalnikowitz D, Sifuentes-Osornio J. Lozano-Cruz OA, et al. Front Pharmacol. 2021 Jun 3;12:668678. doi: 10.3389/fphar.2021.668678. eCollection 2021. Front Pharmacol. 2021. PMID: 34149420 Free PMC article.

See all "Cited by" articles

References

1. Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, Li Y, Hu Z, Zhong W, Wang M.. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov 2020;6:16. - PMC - PubMed
1. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G.. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020;30:269–271. - PMC - PubMed
1. Haeusler IL, Chan XHS, Guerin PJ, White NJ.. The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review. BMC Med 2018;16:200. - PMC - PubMed
1. Huang CL. Murine electrophysiological models of cardiac arrhythmogenesis. Physiol Rev 2017;97:283–409. - PMC - PubMed
1. Jeevaratnam K, Guzadhur L, Goh YM, Grace AA, Huang CL.. Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis. Acta Physiol (Oxf) 2016;216:186–202. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources

[1] Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, Li Y, Hu Z, Zhong W, Wang M.. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov 2020;6:16. - PMC - PubMed

[2] Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, Li Y, Hu Z, Zhong W, Wang M.. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov 2020;6:16. - PMC - PubMed

[3] Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G.. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020;30:269–271. - PMC - PubMed

[4] Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G.. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020;30:269–271. - PMC - PubMed

[5] Haeusler IL, Chan XHS, Guerin PJ, White NJ.. The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review. BMC Med 2018;16:200. - PMC - PubMed

[6] Haeusler IL, Chan XHS, Guerin PJ, White NJ.. The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review. BMC Med 2018;16:200. - PMC - PubMed

[7] Huang CL. Murine electrophysiological models of cardiac arrhythmogenesis. Physiol Rev 2017;97:283–409. - PMC - PubMed

[8] Huang CL. Murine electrophysiological models of cardiac arrhythmogenesis. Physiol Rev 2017;97:283–409. - PMC - PubMed

[9] Jeevaratnam K, Guzadhur L, Goh YM, Grace AA, Huang CL.. Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis. Acta Physiol (Oxf) 2016;216:186–202. - PubMed

[10] Jeevaratnam K, Guzadhur L, Goh YM, Grace AA, Huang CL.. Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis. Acta Physiol (Oxf) 2016;216:186–202. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety

Affiliations

Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety

Author

Affiliations

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources