Antibody responses to SARS-CoV-2 in patients with COVID-19

doi:10.1038/s41591-020-0897-1

. 2020 Jun;26(6):845-848.

doi: 10.1038/s41591-020-0897-1. Epub 2020 Apr 29.

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long^#¹, Bai-Zhong Liu^#², Hai-Jun Deng^#¹, Gui-Cheng Wu^#^{3

4}, Kun Deng^#⁵, Yao-Kai Chen^#⁶, Pu Liao⁷, Jing-Fu Qiu⁸, Yong Lin¹, Xue-Fei Cai¹, De-Qiang Wang¹, Yuan Hu¹, Ji-Hua Ren¹, Ni Tang¹, Yin-Yin Xu², Li-Hua Yu², Zhan Mo², Fang Gong², Xiao-Li Zhang², Wen-Guang Tian², Li Hu², Xian-Xiang Zhang^{3

4}, Jiang-Lin Xiang^{3

4}, Hong-Xin Du^{3

4}, Hua-Wen Liu^{3

4}, Chun-Hui Lang^{3

4}, Xiao-He Luo^{3

4}, Shao-Bo Wu^{3

4}, Xiao-Ping Cui^{3

4}, Zheng Zhou^{3

4}, Man-Man Zhu⁵, Jing Wang⁶, Cheng-Jun Xue⁶, Xiao-Feng Li⁶, Li Wang⁶, Zhi-Jie Li⁷, Kun Wang⁷, Chang-Chun Niu⁷, Qing-Jun Yang⁷, Xiao-Jun Tang⁸, Yong Zhang⁸, Xia-Mao Liu⁹, Jin-Jing Li⁹, De-Chun Zhang¹⁰, Fan Zhang¹⁰, Ping Liu¹¹, Jun Yuan¹, Qin Li¹², Jie-Li Hu¹³, Juan Chen¹⁴, Ai-Long Huang¹⁵

Affiliations

¹ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China.
² Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, China.
³ Chongqing University Three Gorges Hospital, Chongqing, China.
⁴ Chongqing Three Gorges Central Hospital, Chongqing, China.
⁵ The Third Hospital Affiliated to Chongqing Medical University, Chongqing, China.
⁶ Division of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
⁷ Laboratory Department, Chongqing People's Hospital, Chongqing, China.
⁸ School of Public Health and Management, Chongqing Medical University, Chongqing, China.
⁹ The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹⁰ Wanzhou People's Hospital, Chongqing, China.
¹¹ BioScience Co. Ltd, Chongqing, China.
¹² Chongqing Center for Disease Control and Prevention, Chongqing, China.
¹³ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China. 102564@cqmu.edu.cn.
¹⁴ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China. chenjuan2014@cqmu.edu.cn.
¹⁵ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn.

^# Contributed equally.

PMID: 32350462
DOI: 10.1038/s41591-020-0897-1

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al. Nat Med. 2020 Jun.

. 2020 Jun;26(6):845-848.

doi: 10.1038/s41591-020-0897-1. Epub 2020 Apr 29.

Authors

Affiliations

¹ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China.
² Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, China.
³ Chongqing University Three Gorges Hospital, Chongqing, China.
⁴ Chongqing Three Gorges Central Hospital, Chongqing, China.
⁵ The Third Hospital Affiliated to Chongqing Medical University, Chongqing, China.
⁶ Division of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
⁷ Laboratory Department, Chongqing People's Hospital, Chongqing, China.
⁸ School of Public Health and Management, Chongqing Medical University, Chongqing, China.
⁹ The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹⁰ Wanzhou People's Hospital, Chongqing, China.
¹¹ BioScience Co. Ltd, Chongqing, China.
¹² Chongqing Center for Disease Control and Prevention, Chongqing, China.
¹³ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China. 102564@cqmu.edu.cn.
¹⁴ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China. chenjuan2014@cqmu.edu.cn.
¹⁵ Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn.

^# Contributed equally.

PMID: 32350462
DOI: 10.1038/s41591-020-0897-1

Abstract

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.

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References

1. Corman, V. M. et al. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clin. Infect. Dis. 62, 477–483 (2016). - PubMed
1. Li, G., Chen, X. & Xu, A. Profile of specific antibodies to the SARS-associated coronavirus. N. Engl. J. Med. 349, 508–509 (2003). - DOI
1. Hsueh, P. R., Huang, L. M., Chen, P. J., Kao, C. L. & Yang, P. C. Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus. Clin. Microbiol. Infect. 10, 1062–1066 (2004). - DOI
1. Park, W. B. et al. Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea. Emerg. Infect. Dis. 21, 2186–2189 (2015). - DOI
1. Drosten, C. et al. Transmission of MERS-coronavirus in household contacts. N. Engl. J. Med. 371, 828–835 (2014). - DOI

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[1] Corman, V. M. et al. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clin. Infect. Dis. 62, 477–483 (2016). - PubMed

[2] Corman, V. M. et al. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection. Clin. Infect. Dis. 62, 477–483 (2016). - PubMed

[3] Li, G., Chen, X. & Xu, A. Profile of specific antibodies to the SARS-associated coronavirus. N. Engl. J. Med. 349, 508–509 (2003). - DOI

[4] Li, G., Chen, X. & Xu, A. Profile of specific antibodies to the SARS-associated coronavirus. N. Engl. J. Med. 349, 508–509 (2003). - DOI

[5] Hsueh, P. R., Huang, L. M., Chen, P. J., Kao, C. L. & Yang, P. C. Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus. Clin. Microbiol. Infect. 10, 1062–1066 (2004). - DOI

[6] Hsueh, P. R., Huang, L. M., Chen, P. J., Kao, C. L. & Yang, P. C. Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus. Clin. Microbiol. Infect. 10, 1062–1066 (2004). - DOI

[7] Park, W. B. et al. Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea. Emerg. Infect. Dis. 21, 2186–2189 (2015). - DOI

[8] Park, W. B. et al. Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea. Emerg. Infect. Dis. 21, 2186–2189 (2015). - DOI

[9] Drosten, C. et al. Transmission of MERS-coronavirus in household contacts. N. Engl. J. Med. 371, 828–835 (2014). - DOI

[10] Drosten, C. et al. Transmission of MERS-coronavirus in household contacts. N. Engl. J. Med. 371, 828–835 (2014). - DOI

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Antibody responses to SARS-CoV-2 in patients with COVID-19

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Antibody responses to SARS-CoV-2 in patients with COVID-19

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