Using salvage Boron Neutron Capture Therapy (BNCT) for recurrent malignant brain tumors in Taiwan

Tien-Li Lan; Fong-In Chou; Ko-Han Lin; Po-Shen Pan; Jia-Cheng Lee; Wen-Sheng Huang; Yu-Ming Liu; Yee Chao; Yi-Wei Chen

doi:10.1016/j.apradiso.2020.109105

Using salvage Boron Neutron Capture Therapy (BNCT) for recurrent malignant brain tumors in Taiwan

Appl Radiat Isot. 2020 Jun:160:109105. doi: 10.1016/j.apradiso.2020.109105. Epub 2020 Feb 27.

Authors

Tien-Li Lan¹, Fong-In Chou², Ko-Han Lin³, Po-Shen Pan⁴, Jia-Cheng Lee⁵, Wen-Sheng Huang³, Yu-Ming Liu⁵, Yee Chao⁶, Yi-Wei Chen⁷

Affiliations

¹ Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital, Taipei City, Taiwan. Electronic address: tllan@vghtpe.gov.tw.
² Nuclear Science & Technology Development Department, National Tsing-Hua University, Hsinchu, Taiwan.
³ Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan.
⁴ Department of Chemistry, Tamkang University, New Taipei City, Taiwan.
⁵ Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital, Taipei City, Taiwan.
⁶ Department of Oncology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
⁷ Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital, Taipei City, Taiwan. Electronic address: chenyw@vghtpe.gov.tw.

PMID: 32351215
DOI: 10.1016/j.apradiso.2020.109105

Abstract

Radiation therapy has an irreplaceable role in modern oncologic therapy, thanks to the advanced radiation techniques developed in recent decades. However, photon-resistant cases are sometimes encountered. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy technique due to the high tumor to tissue ratio of boronophenylalanine (BPA), the unique medication used for the BNCT treatment reaction. In this study, we report on three special patients with malignant brain tumors treated with BNCT.

Keywords: Boron Neutron Capture Therapy; Mismatch repair syndrome; Recurrent glioblastoma.

MeSH terms

Adult
Boron Neutron Capture Therapy / methods*
Brain Neoplasms / radiotherapy*
Child
Female
Glioblastoma / radiotherapy*
Humans
Male
Middle Aged
Salvage Therapy*