Neonatal management of aortic coarctation with ventricular septal defect: a systematic review and meta-analysis

J Cardiovasc Surg (Torino). 2020 Aug;61(4):478-488. doi: 10.23736/S0021-9509.20.11075-9. Epub 2020 Apr 29.


Introduction: Neonatal management of aortic coarctation with ventricular septal defect is still under debate between the one-stage full repair by sternotomy versus the staged repair of the coarctation first by thoracotomy (with or without banding the pulmonary artery) followed later by subsequent closure of the ventricular septal defect.

Evidence acquisition: The aim of this review was to synthesize the evidence in literature since 1980 for the neonatal population. A meta-analysis compared mortality between the two strategies.

Evidence synthesis: The analysis did not find a superiority of a strategy over the other regardless of the surgical era studied. Recoarctation rates of both strategies are presented and a management algorithm is suggested.

Conclusions: Instead of comparing between the two strategies, a case-adapted management considering the anatomy of the ventricular septal defect and of the aortic arch is discussed to address this association of lesions though presenting with a wide range of settings.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Algorithms
  • Aorta, Thoracic / surgery
  • Aortic Coarctation / mortality
  • Aortic Coarctation / surgery*
  • Heart Septal Defects, Ventricular / mortality
  • Heart Septal Defects, Ventricular / surgery*
  • Humans
  • Infant, Newborn
  • Pulmonary Artery / surgery
  • Sternotomy
  • Thoracotomy