Objectives: This study aimed to compare clinical courses and outcomes between pregnant and reproductive-aged non-pregnant women with COVID-19, and to assess the vertical transmission potential of COVID-19 in pregnancy.
Methods: Medical records of pregnant and reproductive-aged non-pregnant women hospitalized with COVID-19 from January 15 to March 15, 2020 were retrospectively reviewed. The severity of disease, virus clearance time, and length of hospital stay were measured as the primary objective, while the vertical transmission potential of COVID-19 was also assessed.
Results: Eighty-two patients (28 pregnant women, 54 reproductive-aged non-pregnant women) with laboratory-confirmed COVID-19 were enrolled in this study. Univariate regression indicated no association between pregnancy and severity of disease (OR 0.73, 95% CI 0.08-5.15; p=0.76), virus clearance time (HR 1.16, 95% CI 0.65-2.01; p=0.62), and length of hospital stay (HR 1.10, 95% CI 0.66-1.84; p=0.71). Of the pregnant women, 22 delivered 23 live births, either by cesarean section (17, 60.7%) or vaginal delivery (5, 17.9%), and no neonate was infected with SARS-CoV-2.
Conclusions: Pregnant women have comparable clinical courses and outcomes with reproductive-aged non-pregnant women when infected with SARS-CoV-2. No evidence supported vertical transmission of COVID-19 in the late stage of pregnancy, including vaginal delivery.
Keywords: COVID-19; SARS-CoV-2; clinical feature; infection; pregnancy; virus.
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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Effects of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcomes: a systematic review.Ultrasound Obstet Gynecol. 2020 May 19. doi: 10.1002/uog.22088. Online ahead of print. Ultrasound Obstet Gynecol. 2020. PMID: 32430957 Review.
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.Lancet. 2020 Mar 7;395(10226):809-815. doi: 10.1016/S0140-6736(20)30360-3. Epub 2020 Feb 12. Lancet. 2020. PMID: 32151335 Free PMC article.
Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis.Am J Obstet Gynecol MFM. 2020 Mar 25:100107. doi: 10.1016/j.ajogmf.2020.100107. Online ahead of print. Am J Obstet Gynecol MFM. 2020. PMID: 32292902 Free PMC article. Review.
Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis.BJOG. 2020 Apr 27. doi: 10.1111/1471-0528.16278. Online ahead of print. BJOG. 2020. PMID: 32339382