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. 2020 Apr 23;140:109767.
doi: 10.1016/j.mehy.2020.109767. Online ahead of print.

Vitamin D: A Simpler Alternative to Tocilizumab for Trial in COVID-19?

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Vitamin D: A Simpler Alternative to Tocilizumab for Trial in COVID-19?

Morry Silberstein. Med Hypotheses. .
Free PMC article

Abstract

There is anecdotal evidence that tocilizumab, an immunosuppressant drug, may be a potential therapeutic option for patients with severe manifestations of coronavirus disease 2019 (COVID-19). Like tocilizumab, Vitamin D appears to modulate the activity of an interleukin (IL-6), which may explain the seasonal variation in prevalence of influenza. While most cases of COVID-19 have, thus far, occurred in the Northern Hemisphere winter, limiting the ability to assess seasonal variation, there remains substantial variation in the severity of this condition that has yet to be explained. A retrospective comparison of Vitamin D levels in previously obtained blood samples between survivors and confirmed fatalities could establish a rationale for implementation of widespread Vitamin D supplementation. This would be far cheaper and simpler than tocilizumab as a therapeutic option to trial.

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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References

    1. WHO Coronavirus disease 2019 (COVID-19) situation report – 66. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200326-sitrep-66-covid-19.pdf?sfvrsn=81b94e61_2. Published March 26, 2020. Accessed March 27, 2020.
    1. Gianotti G. I'm a doctor at Italy’s hardest-hit hospital. I had to decide who got a ventilator and who didn’t. https://www.abc.net.au/news/2020-03-27/coronavirus-doctor-cremona-hospital-decide-who-lives-and-dies/1209091Published March 27, 2020. Accessed March 27, 2020.
    1. Chinese Clinical Trial Registry: A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19). http://www.chictr.org.cn/showprojen.aspx?proj=49409.
    1. ClinicalTrials.gov: Tocilizumab in COVID-19 Pneumonia (TOCIVID-19). https://www.clinicaltrials.gov/ct2/show/NCT04317092.
    1. Conti P, Ronconi G, Caraffa A, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020 Mar 14;34(2). pii: 1. doi: 10.23812/CONTI-E. [Epub ahead of print]. - PubMed
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