Rodent EEG: Expanding the Spectrum of Analysis

Epilepsy Curr. 2020 May;20(3):149-153. doi: 10.1177/1535759720921377. Epub 2020 Apr 30.


In epilepsy research, the analysis of rodent electroencephalogram (EEG) has been performed by many laboratories with a variety of techniques. However, the acquisition and basic analysis of rodent EEG have only recently been standardized. Since a number of software platforms and increased computational power have become widely available, advanced rodent EEG analysis is now more accessible to investigators working with rodent models of epilepsy. In this review, the approach to the analysis of rodent EEG will be examined, including the evaluation of both epileptiform and background activity. Major caveats when employing these analyses, cellular and circuit-level correlates of EEG changes, and important differences between rodent and human EEG are also reviewed. The currently available techniques show great promise in gaining a deeper understanding of the complexities hidden within the EEG in rodent models of epilepsy.

Keywords: background EEG; cross-frequency coupling; granger causality; phase coherence; spectral analysis.