Long-term Survival With Afatinib in a Patient With Lung Adenocarcinoma Harboring Double Uncommon EGFR L861Q and G719X Mutations

In Vivo. 2020 May-Jun;34(3):1459-1462. doi: 10.21873/invivo.11929.


Background: In the majority of non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations, first generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are ineffective. The second-generation TKI, afatinib, is considered effective in patients with uncommon mutations, however, long-term survivors have been rare.

Case report: We report herein a patient with lung adenocarcinoma harboring double uncommon EGFR L861Q and G719X mutations, who is free of disease 32 months after initiation of afatinib therapy. To our best knowledge, this patient has the longest response among other patients with double uncommon mutations.

Conclusion: Patients with this type of NSCLC may obtain long-term survival with afatinib.

Keywords: Long-term survival; afatinib; lung adenocarcinoma; uncommon EGFR mutations.

MeSH terms

  • Adenocarcinoma of Lung / diagnosis
  • Adenocarcinoma of Lung / genetics*
  • Adenocarcinoma of Lung / mortality*
  • Adenocarcinoma of Lung / therapy
  • Aged
  • Alleles*
  • Amino Acid Substitution
  • ErbB Receptors / genetics
  • Female
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / mortality*
  • Lung Neoplasms / therapy
  • Male
  • Mutation*
  • Prognosis
  • Radiography, Thoracic
  • Tomography, X-Ray Computed


  • EGFR protein, human
  • ErbB Receptors