Decoding the Noncoding Cancer Genome

Cancer Discov. 2020 May;10(5):646-647. doi: 10.1158/2159-8290.CD-20-0285.


In this issue of Cancer Discovery, Li and colleagues provide a blueprint for the identification and functional validation of cancer-associated mutations in noncoding regions of the genome. Integration of whole-genome sequencing and high-throughput epigenome editing screens is starting to reveal the extent to which noncoding genetic lesions contribute to cancer.See related article by Li et al., p. 724.

Publication types

  • Comment

MeSH terms

  • Hematologic Neoplasms*
  • Humans
  • Mutation
  • Neoplasms* / genetics
  • Receptors, Cytoplasmic and Nuclear
  • Regulatory Sequences, Nucleic Acid


  • Receptors, Cytoplasmic and Nuclear