Molecular profile, tissue distribution and prognostic evaluation of a human melanoma-carcinoma antigen recognized by the murine monoclonal antibody B1.1

Int J Biol Markers. Oct-Dec 1988;3(4):211-20.

Abstract

Using the murine monoclonal antibody (MoAb) B1.1 we have analyzed the immunochemical profile and the tissue distribution of a human melanoma associated antigen (MAA) carrying an epitope shared by the 180 kd CEA. Results of this study have demonstrated that the epitope expressed by the MAA is carried by a distinct set of molecules of 110-140 kd. Similarly to the 180 kd CEA molecules synthesized by carcinomas, the expression of the melanoma associated CEA like components (MA-CEA) is upregulated by IFN-alpha. The tissue distribution of MA-CEA is not restricted to malignant primary and metastatic melanocytic lesions but is found also at low levels in 64% of benign nevi. No circulating CEA was found in patients bearing widespread metastatic disease of MA-CEA positive lesions. Preliminary clinical evaluation of stage I melanoma patients bearing MoAb B1.1 positive lesions has not shown a significative prognostic association of this phenotypic marker with clinical course of the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Monoclonal*
  • Antigens, Neoplasm
  • Biomarkers, Tumor / analysis*
  • Biomarkers, Tumor / genetics
  • Carcinoembryonic Antigen / analysis
  • Cell Line
  • Female
  • Gene Expression Regulation
  • Humans
  • Immunohistochemistry
  • Interferon Type I / physiology
  • Male
  • Melanoma / pathology*
  • Melanoma-Specific Antigens
  • Middle Aged
  • Neoplasm Proteins / analysis*
  • Neoplasm Proteins / genetics
  • Prognosis
  • Skin / pathology
  • Skin Neoplasms / pathology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Carcinoembryonic Antigen
  • Interferon Type I
  • Melanoma-Specific Antigens
  • Neoplasm Proteins