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. 2020 May 2;jiaa229.
doi: 10.1093/infdis/jiaa229. Online ahead of print.

Longitudinal Change of SARS-Cov2 Antibodies in Patients With COVID-19

Free PMC article

Longitudinal Change of SARS-Cov2 Antibodies in Patients With COVID-19

Guoxin Zhang et al. J Infect Dis. .
Free PMC article


Background: A novel coronavirus, SARS-CoV-2, has recently emerged and caused the rapid spread of COVID-19 worldwide.

Methods: We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between February 1 and February 29, 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen.

Results: 112 patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhoea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both IgM and IgG, 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post disease onset, and lasted for one month and gradually decreased, while IgG antibody was produced 10 days after infection, and lasted for a longer time. However, no significant difference in level of IgM and IgG antibody between positive and negative patients of nucleic acid test after treatment was found.

Conclusions: Our results indicate that serological tests could be powerful approach for the early diagnosis of COVID-19.

Keywords: COVID-19; SARS-CoV-2; antibody; humoral immunity; serological test.

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