Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

Am J Perinatol. 2020 Jun;37(8):869-872. doi: 10.1055/s-0040-1710541. Epub 2020 May 2.


Objective: To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2.

Study design: This is an observational study of neonates born to mothers with coronavirus disease 2019 (COVID-19).

Results: Seven pregnant women with documented SARS-CoV-2 infection have been evaluated in our institution. One woman had a spontaneous abortion at 8 weeks of gestational age, four women recovered and are still in follow-up, and two women delivered. Two newborns were enrolled in the study. At birth and 3 days of life, newborns were negative to SARS-CoV-2. At 2-week follow-up, one newborn tested positive although asymptomatic.

Conclusion: Our findings highlight the importance of follow-up of newborns to mothers with COVID-19 in pregnancy, since they remain at risk of contracting the infection in the early period of life and long-term consequences are still unknown.

Key points: · Newborns to mothers with coronavirus disease 2019 (COVID-19) in pregnancy can acquire the infection later after birth.. · Newborns to mothers with COVID-19 in pregnancy need a long-term follow-up, even if they tested negative at birth.. · Specific guidelines for the long-term follow-up of newborns to mothers with COVID-19 in pregnancy are needed..

Publication types

  • Observational Study

MeSH terms

  • Abortion, Spontaneous / etiology
  • Aftercare / standards
  • Betacoronavirus / isolation & purification*
  • COVID-19
  • Coronavirus Infections* / complications
  • Coronavirus Infections* / diagnosis
  • Coronavirus Infections* / epidemiology
  • Coronavirus Infections* / physiopathology
  • Delivery, Obstetric / methods
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases* / diagnosis
  • Infant, Newborn, Diseases* / epidemiology
  • Infant, Newborn, Diseases* / physiopathology
  • Infant, Newborn, Diseases* / virology
  • Infectious Disease Transmission, Vertical
  • Italy / epidemiology
  • Male
  • Needs Assessment
  • Outcome and Process Assessment, Health Care
  • Pandemics*
  • Pneumonia, Viral* / complications
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / epidemiology
  • Pneumonia, Viral* / physiopathology
  • Postnatal Care* / methods
  • Postnatal Care* / standards
  • Pregnancy
  • Pregnancy Complications, Infectious* / epidemiology
  • Pregnancy Complications, Infectious* / physiopathology
  • Pregnancy Complications, Infectious* / virology
  • SARS-CoV-2
  • Time Factors