Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

Trends Neurosci. 2020 Jun;43(6):355-357. doi: 10.1016/j.tins.2020.04.004. Epub 2020 Apr 21.


Emerging evidence indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can cause neurological complications. We provide a brief overview of these recent observations and discuss some of their possible implications. In particular, given the global dimension of the current pandemic, we highlight the need to consider the possible long-term impact of COVID-19, potentially including neurological and neurodegenerative disorders.

Keywords: COVID-19; Parkinson’s disease; anosmia; encephalitis; neurodegenerative diseases; neurological alterations.

Publication types

  • Review

MeSH terms

  • Animals
  • Betacoronavirus / pathogenicity*
  • COVID-19
  • Central Nervous System / virology*
  • Coronavirus Infections / virology*
  • Humans
  • Nervous System Diseases / virology*
  • Pandemics
  • Pneumonia, Viral / virology*
  • SARS-CoV-2