Modulation of Hb-O2 affinity to improve hypoxemia in COVID-19 patients

Simon Woyke; Simon Rauch; Mathias Ströhle; Hannes Gatterer

doi:10.1016/j.clnu.2020.04.036

Modulation of Hb-O₂ affinity to improve hypoxemia in COVID-19 patients

Clin Nutr. 2021 Jan;40(1):38-39. doi: 10.1016/j.clnu.2020.04.036. Epub 2020 Apr 28.

Authors

Simon Woyke¹, Simon Rauch², Mathias Ströhle³, Hannes Gatterer⁴

Affiliations

¹ Department of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
² Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy; Department of Anesthesia and Intensive Care Medicine, "F. Tappeiner" Hospital, Merano, Italy.
³ Department of General and Surgical Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
⁴ Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy. Electronic address: hannes.gatterer@eurac.edu.

Abstract

This opinion paper aims at discussing the potential impact of modulating the Hb-O₂ affinity by the nutritional supplement 5-HMF on patients affected by COVID-19. The paper describes the critical role of the oxygen affinity in hypoxemic COVID-19 patients and the potential positive effect of 5-HMF, a compound shown to increase the Hb-O₂ affinity.

Keywords: 5-Hydroxymethylfurfural; COVID-19; Nutritional supplement.

Publication types

Review

MeSH terms

COVID-19 / complications*
Dietary Supplements*
Furaldehyde / analogs & derivatives*
Furaldehyde / therapeutic use
Hemoglobins / drug effects*
Humans
Hypoxia / drug therapy*
Hypoxia / etiology*
Oxygen / blood

Substances

Hemoglobins
5-hydroxymethylfurfural
Furaldehyde
Oxygen