Modulation of Hb-O2 affinity to improve hypoxemia in COVID-19 patients

Clin Nutr. 2021 Jan;40(1):38-39. doi: 10.1016/j.clnu.2020.04.036. Epub 2020 Apr 28.


This opinion paper aims at discussing the potential impact of modulating the Hb-O2 affinity by the nutritional supplement 5-HMF on patients affected by COVID-19. The paper describes the critical role of the oxygen affinity in hypoxemic COVID-19 patients and the potential positive effect of 5-HMF, a compound shown to increase the Hb-O2 affinity.

Keywords: 5-Hydroxymethylfurfural; COVID-19; Nutritional supplement.

Publication types

  • Review

MeSH terms

  • COVID-19 / complications*
  • Dietary Supplements*
  • Furaldehyde / analogs & derivatives*
  • Furaldehyde / therapeutic use
  • Hemoglobins / drug effects*
  • Humans
  • Hypoxia / drug therapy*
  • Hypoxia / etiology*
  • Oxygen / blood


  • Hemoglobins
  • 5-hydroxymethylfurfural
  • Furaldehyde
  • Oxygen