Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders

Neuroscience. 2020 Oct 1;445:190-206. doi: 10.1016/j.neuroscience.2020.04.037. Epub 2020 Apr 29.

Abstract

Disruptions in the gene encoding methyl-CpG binding protein 2 (MECP2) underlie complex neurodevelopmental disorders including Rett Syndrome (RTT), MECP2 duplication disorder, intellectual disabilities, and autism. Significant progress has been made on the molecular and cellular basis of MECP2-related disorders providing a new framework for understanding how altered epigenetic landscape can derail the formation and refinement of neuronal circuits in early postnatal life and proper neurological function. This review will summarize selected major findings from the past years and particularly highlight the integrated and multidisciplinary work done at eight NIH-funded Intellectual and Developmental Disabilities Research Centers (IDDRC) across the US. Finally, we will outline a path forward with identification of reliable biomarkers and outcome measures, longitudinal preclinical and clinical studies, reproducibility of results across centers as a synergistic effort to decode and treat the pathogenesis of the complex MeCP2 disorders.

Keywords: animal models; biomarkers; neurodevelopmental disorders; signaling pathways; translational.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carrier Proteins
  • Child
  • Developmental Disabilities
  • Humans
  • Methyl-CpG-Binding Protein 2* / genetics
  • Methyl-CpG-Binding Protein 2* / metabolism
  • Mutation
  • Reproducibility of Results
  • Rett Syndrome* / genetics

Substances

  • Carrier Proteins
  • MECP2 protein, human
  • Methyl-CpG-Binding Protein 2