Mexilitene use in pregnancy

J Perinatol. 1988 Winter;8(1):33-5.

Abstract

Mexilitene, a class 1b antiarrhythmic, was used throughout an entire pregnancy to treat symptomatic premature ventricular contractions in a patient with mitral valve prolapse. Cord blood and maternal serum mexilitene levels at the time of delivery are given. The following conclusions were reached. (1) Mexilitene may have a future in treating pregnant patients with arrhythmias unresponsive to currently approved antiarrhythmic drugs. (2) Evidence to date has shown no adverse affects in infants of mothers breast-feeding while taking mexilitene. (3) Dosages need to be monitored carefully during pregnancy and the postpartum period to ensure that therapeutic drug levels are maintained.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arrhythmias, Cardiac / blood
  • Arrhythmias, Cardiac / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Heart Ventricles
  • Humans
  • Mexiletine / adverse effects
  • Mexiletine / blood
  • Mexiletine / pharmacokinetics
  • Mexiletine / therapeutic use*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / blood
  • Pregnancy Complications, Cardiovascular / drug therapy*

Substances

  • Mexiletine